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 SM ISO690:2012VIŞNEVSCHI, Anatolie. Modificarea indicilor hemodinamici şi ai markerilor biochimici în şocul hemoragic experimental resuscitat prin asocierea
Difetur-Dextran 70. In: Curierul Medical, 2010, nr. 3(315), pp. 195-200. ISSN 1875-0666. |
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| Curierul Medical | ||||||
| Numărul 3(315) / 2010 / ISSN 1875-0666 | ||||||
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| Pag. 195-200 | ||||||
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Modifications of Hemodynamic and Biochemical Markers in Experimental Hemorrhagic Shock Resuscitated by the Combination
of Difetur-Dextran 70
Hemorrhagic shock influences immune and hemodynamic homeostasis as well as enzymemia. Arterial hypotension during hemorrhagic shock
contributes to the development of tissue hypoperfusion leading to cell damage in the main vital organs. An increased level of pro-inflammatory
cytokines (IL-1α, IL-6 and TNFα) and a decreased level of anti-inflammatory cytokines (IL-10) lead to the development of SIRS. In rats with
hemorrhagic shock, the resuscitation by administration of Difetur-Dextran combination leads to a recovery of hemodynamic indices and a
significant decrease of pro-inflammatory cytokines. Another effect of Difetur-Dextran combination is to decelerate cells damage expressed by
decreased levels of GGTP, GLDH, LDH, CK and pancreatic amylase. |
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| Cuvinte-cheie hemorrhagic shock, cytokines, Difetur, Dextran |
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