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SM ISO690:2012 TOFAN, Elena, GONCIAR, Veaceslav, BUTOROV, Ivan, NECULA, Gheorghe, BUTOROV, A., VÎRTOSU, Parascovia. Eficienţa clinică a losartanului, a lisinoprilului şi asocierii lor în tratamentul insuficienţei cardiace cronice. In: Curierul Medical, 2010, nr. 3(315), pp. 125-129. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(315) / 2010 / ISSN 1875-0666 | ||||||
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Pag. 125-129 | ||||||
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Clinical Effectiveness of Losartan, Lisinopril and their Combination in Chronic Heart Failure
The study included 60 patients with stable symptomatic CHF of II-IV functional class and ejection fraction (EF) of the left ventricle ≤ 45%.
All patients completed a set of diagnostic procedures to determine the diagnosis and received severity of hemodynamic disorders and were
divided into 3 groups. Group I included 20 patients receiving Losartan, group II (n = 20) Lisinopril, and group III (n = 20) received combined
therapy Losartan Lisinopril. Monitoring of the patients lasted 24 weeks. It was established that the combined therapy of Losartan and Lisinopril
determined a quicker (3-4 days) diminishing of clinical symptoms of CHF compared to monotherapy. The effects of Losartan, Lisinopril and
their combination on morpho-functional indices of the heart manifested by decreasing the size of the left heart chambers and improving the
contractile function of left ventricle myocardium, the prevalence of these changes related more to the combined therapy. |
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Cuvinte-cheie Losartan, chronic heart failure, combined therapy, Lisinopril |
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