The demographic crisis in the Republic of Moldova is characterized by the birth rate decrease (77,1 per thousand births in 1990, compared with 39,4 thousand births in 2012), a negative natural increase since 1999, the high emigration of the population of reproductive age and relative growth of total mortality rates ( 9,7/1,000 in 1990, compared to 11,1/1,000 in 2012.) Although the above indexes indicate the depopulation trend, the improvement and modernization of medical perinatal care have greatly reduced perinatal and neonatal mortality. Ambiguous situation is observed while analysing maternal mortality. The Republic of Moldova has proposed to implement the Tasks nr. 5 and 6 based on the example of the international implementation. Table 1 shows the expected and the achieved results in 2006, 2010 and 2012, as well as the expected results in 2015 on the example of children aged 0-5 years, as well as on the example of their mothers. The table shows that in 2006, MDG-5 has been reached by all indicators. Given the fact that the offi cial registration of live- and stillborn has accepted the WHO criteria only in 2008, in 2010 the achieved results have exceeded the expected indixes of about 2/1000. The analysis of indicators of perinatal mortality (PM) dinamics has shown that it has been a decrease of approximately 52% over the 1990-2012 period (from 15,8 ‰ to 8,3 ‰ in the weight category of> 1000 g and 24,2 ‰ to 11 , 6 ‰ in the weight category of 500 g). The PM indicator in the country in 2012 was 11,6 per 1,000 live births and stillbirths, and was slightly lower than in 2011 by 8%.