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841 44 |
Ultima descărcare din IBN: 2023-11-30 16:23 |
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615.322:616.8-053.2-08 (1) |
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Инфекционные заболевания. Инфекционные лихорадки (963) |
SM ISO690:2012 COSTEA, Raluca-Maria, NEAMŢU, Mihai-Leonida, NEAMŢU, Mihai-Bogdan. Antioxidanţii (resveratrolul) - posibile terapii adjuvante în profilaxia recurenţei convulsiilor febrile. In: Buletin de Perinatologie, 2017, nr. 1(73), pp. 54-59. ISSN 1810-5289. |
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Buletin de Perinatologie | |||||
Numărul 1(73) / 2017 / ISSN 1810-5289 | |||||
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CZU: 615.322:616.8-053.2-08 | |||||
Pag. 54-59 | |||||
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Febrile Seizures (FS) are the most common epileptic type events in the pediatric age group. The risk of recurrence and their potentia l role in epileptogenesis entail the detection of the underlying mechanisms, thus identifying new therapeutic alternatives to the known antiepileptic prophylaxis. Recently increasing evidence justify the association between oxidative and nitrosative mitochondrial stress and epilepsy or FS. The FS are placed in the context of a persistent inflammatory process and in specific cases (hippocampal sclerosis) even as a promoter of neuronal destruction and epileptogenesis. A review of the literature supports in vivo studies in animal models and in humans with seizures the potential role of antioxidant therapy in limiting lesions induced by free radicals. Thus, as a potent antioxidant, Resveratrol is emerging as a possible complementary therapy in preventing recurrent CF and epileptigenesis. But in the pediatric practice its role remains controversial and its applicability limited despite a significant number of in vivo animal studies, due to fewer studies with human subjects. The recording of both prooxidant and antioxidant effect of this polyphenol in comparative studies on different organ (in the context of dose-dependent effect, variable affinity of the specific membrane receptors to transresveratrol and different levels of transition metals) requires further research. |
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Cuvinte-cheie stres oxidativ, inflamație, convulsii febrile, epilepsie, antioxidanţi, resveratrol |
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