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SM ISO690:2012 POPUSHOI, Ana, GULYA, Aurelian, BARBA, Nicanor, ROY, Jenny, POIRIER, Donald. Substituted 1,3-phenyl(pyridyl) propenones and derivatives with thiosemicarbazidic groups. Structrure – (hl-60) antileukemia activity relationship. In: Chemistry Journal of Moldova, 2014, nr. 2(9), pp. 67-73. ISSN 1857-1727. DOI: https://doi.org/10.19261/cjm.2014.09(2).10 |
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Chemistry Journal of Moldova | ||||||
Numărul 2(9) / 2014 / ISSN 1857-1727 /ISSNe 2345-1688 | ||||||
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DOI:https://doi.org/10.19261/cjm.2014.09(2).10 | ||||||
CZU: [547+544+579.61]:615.12 | ||||||
Pag. 67-73 | ||||||
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3-(4-(Dimethylamino)phenyl-1-(4-isothiocyanatophenyl)prop-2-en-1-one was obtained from the corresponding N,N-dimethylthyoureas by elimination of dimethylamine at heating with gaseous hydrogen chloride in chloroform and 1-(4-isothiocyanatophenyl)-3-(pyridin-2-il)prop-2-en-1-one by treating 1,1-dimethyl-3-(4-(3-(pyridin-2-il)-acryloyl)-phenyl)thyourea with acetic anhydride. For all obtained compounds in the course of reaction the antileukemia activity was investigated |
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Cuvinte-cheie chalcones, isothiocyanatopropenones, thioureas, antileukemia activity |
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