|Conţinutul numărului revistei|
|Ultima descărcare din IBN:|
| SM ISO690:2012|
, ; ,. Particularităţile clinice, paraclinice şi sistemului prooxidant în artrita juvenilă idiopatică. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”. 2010, nr. 5(11), pp. 214-222. ISSN 1857-1719.
|Analele Ştiinţifice ale USMF „N. Testemiţanu”|
|Numărul 5(11) / 2010 / ISSN 1857-1719|
The clinical, laboratory and prooxidant system peculiarity in juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) is a disease with a complex pathogenesis being involved
in the process, a lot of imunopathogenetic reactions, including the formation of oxidative stress components. The study is focused on determining the clinical, laboratory of arthritis syndrome and the prooxidant system in 90 children with JIA. The study of the clinical features in patients with JIA has noted the presence of fever in 15 children with the appearance of skin rash in 10 children, hepatomegaly in 64%, 10% spleenomegaly, carditis and nephritis – 12,2%, pneumonia – 11,1%, pharyngitis and tonsillitis – 20,1%. The exam of the osteoarticulary system has determined an equal damage of the right and left joint with the prevalence of pain and swelling. Paraclinically, the prevalence of the I-st degree in the disease activity was determined (52,2%), functional class II-nd after Steinbroker (63,3%) and the II-nd radiological stage after Steinbroker (73,3%). The prooxidant indicators study depends on the clinical form of JIA, determined an increased total prooxidant activity (APT) and malonic dialdehyde (DAM) in the systemic form, followed by polyarticulary form and then by the oligoarticulary form. The early, intermediate and late lipid hydroperoxides (HPL) alues, were higher in oligoarticulary form, followed by systemic and polyarticulary form.
Prooxidant indices are directly related to the degree of disease activity in children with
JIA. Thus, the study of prooxidant indicators depending on the degree of disease activity noted an elevated total prooxidant activity and malonic dialdehyde in the III-nd degree of disease activity, followed by the II-nd degree of activity, and the by I-st degree of activity.