As a result of studying septic-purulent infections in Chisinau city it was determined that mainly these one are registered among patients with surgical profile and represents from 41, 6% to 62, 9% from general morbidity. The nosologic structure is predominated by pus wounds (34,3%), post operation abscess (21,8%), phlegmon (11,6%), osteitis (9,7%), pneumonia, bronchopn e u m o n i a ( 7 , 7 % ) , peritonitis (5,9%). The highest share of HSPI was determined at abdomen cavity bodies - 57,3%. The ratio of cordial - vascular system infections decreased from 6,7% in 2000 to 1,9% in 2007. HSPI are determined by a large spectrum of micro organisms: E.coli, S.aureus, S.epidermidis, P.aeruginosa, Klebsiella. Micro organisms are resistant to antibiotic in 60,8% of cases. HSPI appear due to internal and external factors, as well due to infringement of sanitary regulations by public medical institutions.