There are presented the results of examination of 8511 patients: for the pathogenic flora – 2685, for intestinal microflora – 5380 and for intestinal dysbacteriosis – 446 in this article. The pathogen agents were detected in 18,7% patients investigated for pathogenic flora and in 9,5% investigated for condition pathogenic flora. The causal factors for the patients examined for the intestinal flora were determined in 71,5%, for those with dysbacteriosis – in 72,9% cases, including the microbian associations. It was defined the high level of resistance for different antibiotics of pathogen and the same for condition pathogen agents. Only 11,8% of cultures were sensible for the all utilized preparations. The resistance for 1-5 preparations was observed in 57,1%, for 6-10 – in 24,4%, for 11-15 – in 5,7% and for more then 15 preparations – in 0,7% cultures. For the purpose to prevent the polyresistance it is necessary to improve the microbiological diagnosis, to elaborate and realized the National Strategy in these problems.