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SM ISO690:2012 COSTIN, Maria, COTELEA, Tamara, LÎSÎI, Leonid. Studiul paracetamolului în lichidele biologice. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2008, nr. 1(9), pp. 306-309. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(9) / 2008 / ISSN 1857-1719 | ||||||
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Pag. 306-309 | ||||||
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Paracetamol Study in the Biological Liquids
We used Paracetamol phisico-chemical methods in the pure substance for its analysis in the blood plasma. The identification FeCl3 reaction, Nessler reagent, Liebermann. Chromatography on the thin layer in the ethylacetate-metanol-ammonia 25 % (85:10:5) there were used. FeCl3 is used as an eluent, obtaining Rf = 4.5 cm. There was used UV spectrophotometric method in the hydroxide for identification obtaining maximum absorption on 244 and 258 wave lengths pH = 3,0 value of the extraction medium with chloroform organic extragent, as well as HPLC method
was elaborated in order to determine the purity of substance. The used methods where applied according to chemico-toxicological analysis conditions of Paracetamol in the biological liquids. |
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