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Articolul urmator |
980 5 |
Ultima descărcare din IBN: 2023-05-11 21:00 |
SM ISO690:2012 MUSTEAŢĂ, Vasile. Factorii de prognostic în leucemia mieloidă cronică. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2012, nr. 3(13), pp. 317-326. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 3(13) / 2012 / ISSN 1857-1719 | ||||||
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Pag. 317-326 | ||||||
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Prognostic factors in chronic myeloid leukemia
The current study enrolled 125 patients with chronic myeloid leukemia (CML), who had been followed up and treated at the Institute of Oncology in 2005 - 2011. The diagnosis was established in the late chronic phase in 113 (90.4 ± 2.32%) cases and in the accelerated phase in 12 (9.6 ± 2.02%) cases. The severity of the disease and the limited life expectation were proved by the relatively low values of the overall survival: 3- and 5-year survival made up 57.5% şi 36.5%, respectively. In the GIPAP affiliated investigational batch the one-year, 2- and 3-year survival rates constituted 97%, 78% şi 62%, respectively, and turned to be superior to those in the investigational batch without imatinib mesylate treatment.The median longevity (61.65 ± 4.81 years) proved to be much higher (P < 0.05) in the age group of 40 – 49 years. The masculine gender, the diagnosis assertion within 2 and more months after the onset of CML and the ECOG-WHO score of 2 – 3 points after the induction chemotherapy may be considered as unfavorable prognostic factors. |
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