Advantages of the refractometric method in the analysis of combined pharmaceutical forms
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Формы лекарственных средств. Медицинские материалы. Оборудование (99)
Спектральные методы анализа. Оптические методы анализа (65)
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COJOCARI, Cristina, MAZUR, Ecaterina, UNCU, Livia. Advantages of the refractometric method in the analysis of combined pharmaceutical forms. In: Direcții de reformare a sistemului farmaceutic din perspectiva cursului european al Republicii Moldova, Ed. Ediția a 2-a, 28 aprilie 2023, Chişinău. Comrat: Universitatea de Stat din Comrat, 2023, Ediția a 2-a, pp. 133-134. ISBN 978-5-88554-205-0.
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Direcții de reformare a sistemului farmaceutic din perspectiva cursului european al Republicii Moldova
Ediția a 2-a, 2023
Conferința "Direcții de reformare a sistemului farmaceutic din perspectiva cursului european al Republicii Moldova"
Ediția a 2-a, Chişinău, Moldova, 28 aprilie 2023

Advantages of the refractometric method in the analysis of combined pharmaceutical forms

CZU: 615.45.074:543.452

Pag. 133-134

Cojocari Cristina, Mazur Ecaterina, Uncu Livia
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 17 mai 2023


Rezumat

Introduction. Refractometry is one of the oldest and most widely used non-spectral optical methods for the analysis of pharmaceutical substances. This method is based on the measurement of the refractive index, which allows the determination of purity and concentrations of medicinal substances in solutions. Determinations are made by using an instrument called refractometer (mechanical or electronic). It is used to calculate the optical refractive index (n) of a substance or a mixture of substances, which is a non-dimensional parameter and can be defined as the ratio of the velocity of light in both media. Aim of the study. Bibliographic evaluation of the possibilities to apply the refractometric method in the analysis and comparison with other methods. Material and methods. Advanced bibliographic study by accessing Cochrane Electronic Library, MEDLINE databases, CAB Abstracts © CAB and SciSearch © The Thomson Corporation; 45 scientific articles were assessed. Results. By reviewing the scientific articles, it was concluded that the most important advantage of refractometry is the taking of measurements in a very fast way. Compared to most other chemical analytical methods, it is non-destructive, economical, simple in handling and allows a rapid determination of solution concentrations. Refractometry has been successfully applied in the analysis of antimalarial drugs, known as a simple and accessible technique for a rapid assessment of their quality. The method has also been tested for the analysis of anesthetic drug mixtures, and it has been concluded that it can be a useful tool to assess the concentration of single drug solutions or to check the accuracy of drug combination mixtures [1]. At the same time, from the evaluated sources it can be concluded the possibility of applying refractometry in the analysis of proteins, at the fractionation and purification stage, as an alternative to the laborious pharmacopoeial methods [2]. Refractometric detection is widely used in high-pressure liquid chromatography (HPLC), especially for substances that do not possess absorbance in the UV region [3]. Conclusions. The refractometric method possesses a number of advantages in use by being simple, rapid, accessible, non-destructive, economical, and it also can be combined with HPLC and applied in the analysis of combined pharmaceutical forms.

Cuvinte-cheie
refractometry, combined pharmaceutical forms, refractive index