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Ultima descărcare din IBN: 2023-08-27 05:00 |
SM ISO690:2012 ROTARU, Daniela, ROTARU, Lyudmila I.. Malocclusion - genetic aspects. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 539. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 539-539 | ||||||
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Background. Dental malocclusion or dento-maxillary anomalies means an abnormal teeth relation between upper and lower jaw, influenced by genetics and environmental factors. Objective of the study. The study of genetic aspects in the development of malocclusions. Material and Methods. Data from the scientific literature have been studied and analyzed using the PubMed, Google Scholar, Hinari databases. Results. The heritability coefficient higher than 60% and family aggregation confirm the genetic nature of malocclusions, the multifactorial determinism of dento-maxillary anomalies, but also the autosomal-dominant heredity of some types (malocclusion class II and III). Approximately 150 genes / loci are associated with craniofacial abnormalities with malocclusions. Candidate genes involved in bone development have been described: FGFR2, COL1A1, PAX9, TGFB3, LTBP, IGF1, ENPP1, EVC, RUNX2 and NOG; genes involved in cartilage development: GHR and Matrilin1; genes involved in muscle development: MYO1H, ACTN3, CAT6B and DUSP6; genes responsible for tooth morphogenesis: EDA, XEDAR and BMP2. Some genes expressed in facial soft tissue: ARHGAP29, PRDM16, PAX3, TP63, C5orf50, Col17A1, HMGA2, AJUBA and ADK are responsible for facial symmetry, face width and height. Conclusion. The correct diagnosis of the etiology of malocclusion with hereditary determinism represents the success of orthodontic treatment, individualizing the treatment plan specific to the clinical case and the most accurate prognosis of long-term maxillofacial changes. |
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Cuvinte-cheie genetic, Gene, malocclusion, genetica, gene, malocluzie |
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