There are different forms of exclusion a person from society: economic, cultural and social exclusion. In addition, there are a lot of structural reasons for exclusion from society that are not related to a person’s personal choice, and there are also different degrees of social exclusion. The main subject of the study is the methodology for assessing social exclusion, and the main goal is to adapt the methodologies used in European countries for the Republic of Moldova. This paper has been developed within the framework of the Scientific Project for the period 2020-2023, registered in the State Register of projects in the field of science and innovation of the Republic of Moldova with the code 20.80009.0807.29 Proiect Program de Stat ”Perfecționarea mecanismelor de aplicare instrumentelor inovaționale orientate spre creșterea durabilă a bunăstării populației Republicii Moldova” / Project State Program ”Improving the mechanisms for applying innovative instruments aimed at sustainably increasing the welfare of the population of the Republic of Moldova”.