Due to the global warming of the climate, plants are exposed to unfavorable conditions caused by both high temperatures and negatively low temperatures in different periods of de-velopment. Such abiotic stress events can cause fundamental changes in the functional state of plants or even negative impact with repercussions on plant productivity and the rural economy [1]. That is why, at present, the fundamental requirements of modern agriculture for specialists in this field is to ensure a guaranteed harvest under conditions of abiotic stress. For this purpose, it is necessary to integrate the methods of physico-chemical biology in ecological agriculture to obtain stable harvests.  In the territory of the Republic of Moldova, in general, plants suffer from winter frosts, drought and summer heat, which makes them much more vulnerable to pests, mycoses and other pathogens. Solving this problem by applying synthetic substances is already out of date, because it leads to the emergence of ecological crises. Obtaining an ecologically harmless harvest has become the primary aim for most producers. Research dedicated to studying the mechanisms of action of biologically active substances offers new opportunities in increasing the level of plant adaptation by inducing resistance systems with the help of biostimulators. Biostimulators condition the reactions, which improve the plants’ resistance to different stress factors. Although biostimulators do not have pathogen-eliminating effects, they still contribute to increasing the genetic potential of plant resistance to fight infections through gene products and metabolites.  Among the harmless biostimulators for ecological agriculture and human health is Re-glalg, extracted from algae. The most sensitive indicator of the plant’s state under the influence of exogenous factors is the modification of germination parameters. A suitable model for stu-dying the germination reaction is the seeds of plants that were previously treated with a biosti-mulator and were exposed to temperature shock. This is due to the fact that at the initial stages of ontogenesis plant seeds germinate quickly, having small sizes, which provides the exact establishment of the smallest changes in the germination processes. Therefore, the purpose of this study was to determine the effect of the treatment with the biostimulator Reglalg and tem-perature shock on the germination of seeds of winter wheat’s genotypes grown in the fields in different years under different environmental conditions.