În acest articol a fost descris programul complex de screening al familiilor cu risc sporit de cancer ereditar (cancerul organelor reproductive la femei), care oferă posibilitatea de a înţelege mai bine biologia procesului malign şi permite precizarea mecanismelor patogenezei neoformaţiunilor maligne şi a celor primar-multiple ale organelor sistemului reproductiv la femei. Au fost elaborate criterii ale riscului pentru rudele bolnavilor cu cancer endometrial, cancer ovarian, cancer mamar, cancer colorectal şi neoformaţiuni maligne primar-multiple în funcţie de factorii medico-genetici şi clinici. A fost creat algoritmul depistării timpurii a cancerului în familiile cu risc oncologic sporit ereditar (cancerul organelor reproductive la femei). Aceasta dă posibilitatea de a efectua monitoringul bolnavilor oncologici şi al rudelor afectate de neoformaţiuni maligne şi/ sau benigne din familiile cu risc ereditar de îmbolnăvire, va permite evidenţierea oncopatologiei la etapele cele mai timpurii şi justifi carea abordărilor profi laxiei secundare a neoformaţiunilor maligne.

In this article the complex screening program for families with high hereditary cancer risk (cancer of female reproductive organs) is represented. It’s offer the possibility to have a better understanding of malign process and allow to itemize the pathogenic mechanism of new formed maligns and primary multiple ones of female reproductive system parts. A range of risk criteria, conditioned by hereditary and clinical conditions, for relatives of patient with endometrial cancer, ovarian cancer, breast cancer, colorectal cancer, primary multiple tumors was elaborated. An algorithm of advanced hunting out of cancer in families with high hereditary cancer risk (cancer of female reproductive organs) was elaborated. Both of them allow screening of patients and their relatives form families with high hereditary cancer risk, affected by malignant or benign formation, will allow to organize the screening an the primary stage and will justify the usage of secondary prophylaxis measures of malign formations.

В этой статье описана комплексная программа скрининга высокораковых семей, которая поможет лучше понять биологию злокачественного процесса и позволит уточнить механизмы патогенеза злокачественных новообразований органов репродуктивной системы у женщин и ПМЗН. Разработаны критерии риска для родственников онкологических больных с наследственными синдромами, РТМ, РЯ, РТК и ПМЗН в зависимости от медико-генетических и клинических факторов. Результаты внедрения в клиническую практику такого подхода позволят рекомендовать его в качестве модели для создания в системе противораковой борьбы нового направления – системы онкогенетической профилактической помощи лицам с отягощенным онкопатологическим генотипом.