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SM ISO690:2012 REVENCO, Ninel, CRACEA (DRUŞCA), Angela. Tratamentul antioxidant în artrita juvenilă idiopatică. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 5(12), pp. 219-231. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 5(12) / 2011 / ISSN 1857-1719 | ||||||
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Pag. 219-231 | ||||||
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Rezumat | ||||||
Antioxidant treatment in juvenile idiopathic arthritis
In juvenile idiopathic arthritis (JIA), production of oxygen free radicals exceeds
the capacity of cellular antioxidants.
The purpose of this study was to determine the efficacy of the antioxidant preparation
(Extract Vita Grapes) on indices of clinical, laboratory, prooxidant and antioxidant system
indices in children with JIA.
50 patients with JIA were included in the treatment phase. Their background
medication (Methotrexate, Prednisolone) comprised the antioxidant preparation (Extract Vita
Grapes) for 3 months. Children were divided into the following groups: I group -14 children with
JIA who followed treatment with Methotrexate and antioxidant preparation, IIgroup -
12 children with JIA were administred treatment with Methotrexate, Prednisolone and
antioxidant preparation, III group - 24 children with JIA who followed treatment with
Methotrexate and placebo. All these 50 patients initially and after 3 months of treatment
with antioxidant preparations were evaluated by a specially developed protocol (clinical,
laboratory, prooxidant and antioxidant system indices were investigated).
Resveratrol has an antioxidant action; it binds and removes free radicals from the
body. Thus, the total prooxidant activity (APT) and malonic dialdehyde activity(MDA) in
groups I and II after the antioxidant treatment have noted much lower levels compared to
baseline ones while ATP and MDA in group III had only a tendency to decrease. |
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