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SM ISO690:2012 TOCARCIUC, Ina, FRIPTU, Valentin, CARDANIUC, Corina, SURGUCI, Mihail, BÎTCĂ, Tamara, TODIRAŞ, Mihail. Nivelul seric al prostaglandinelor E2 şi F2α la pacientele cu dismenoree primară. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 5(12), pp. 30-33. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 5(12) / 2011 / ISSN 1857-1719 | ||||||
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Pag. 30-33 | ||||||
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Serum levels of prostaglandins Е2 and F2α in patients with primary dysmenorrheal
Dysmenorrhoea is a common gynecological problem representing painful cramps
accompanying menstruation which in the absence of underlying pathology is called primary
dysmenorrhea. Progresses in studying the biochemistry of prostaglandins and their role in the
pathophysiology of primary dysmenorrhea have established a rational basis for this disorder. The
present study was designed to investigate serum levels of prostaglandin F2α and Е2 in patients
with primary dysmenorrhea, to assess their role in the pathogenesis of these pathology. Our
results show higher serum concentrations of PGE2 and PGF2α in patients with primary
dysmenorrhea, compared with patients without dysmenorrhea. For patients with primary
dysmenorrhea is characteristic increased plasma levels of PGE2 and PGF2α in the first phase of
the menstrual cycle, when there is the maximum expression of clinical symptoms, compared
with phase II of the menstrual cycle. These data suggest the importance of PGE2 and PGF2α in
the pathogenesis of primary dysmenorrhea. |
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