Currently, the global community is facing a unique pandemic crisis, which due to mechanisms of economic globalization will inevitably influence political, social and economic life of the Republic of Moldova. The picture of the influence of global pandemic crisis on domestic economy is complex and, to some extent, contradictory. Its study is complicated by the fact that since 1989 it has been in a state of continuous economic crisis with different periods of manifestation and tension. The impact of the pandemic crisis on the economy of the Republic of Moldova is to be studied through the prism of two interconnected dimensions: economic and financial. From an economic point of view, the pandemic crisis affected the country's industrial production, services and trade. In terms of financial aspects, the COVID-19 crisis has affected the financial situation of economic agents in different sectors of the economy, the functioning of some segments of the financial market, as well as the monetary balance. The results of study are important for the implementation of anti-crisis measures both at the national level and at the level of branch and economic agents.