CEE-D_PS: Amorphous and crystalline preparation of β-cyclodextrin complexes loaded with dehydroabietiic acid and chromenol-triazole hybrid
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2023-11-23 09:56
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ZVEAGHINTSEVA, Marina, STYNGACH, Evgenia, POGREBNOI, Serghei, LUPAŞCU, Lucian, BARBA, Alic, DUKA, Gh., VALICA, Vladimir, UNCU, Livia, KRAVTSOV, Victor, TERTEAC, Dumitru, BRÎNZAN, Alexandru, MAKAEV, Fliur. CEE-D_PS: Amorphous and crystalline preparation of β-cyclodextrin complexes loaded with dehydroabietiic acid and chromenol-triazole hybrid. In: Ecological and environmental chemistry : - 2022, Ed. 7, 3-4 martie 2022, Chișinău. Chisinau: Centrul Editorial-Poligrafic al USM, 2022, Ediția 7, Vol.1, p. 0. ISBN 978-9975-159-07-4.. 10.19261/eec.2022.v1
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Ecological and environmental chemistry
Ediția 7, Vol.1, 2022
Conferința "Ecological and environmental chemistry 2022"
7, Chișinău, Moldova, 3-4 martie 2022

CEE-D_PS: Amorphous and crystalline preparation of β-cyclodextrin complexes loaded with dehydroabietiic acid and chromenol-triazole hybrid


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Zveaghintseva Marina1, Styngach Evgenia1, Pogrebnoi Serghei12, Lupaşcu Lucian1, Barba Alic1, Duka Gh.1, Valica Vladimir2, Uncu Livia2, Kravtsov Victor3, Terteac Dumitru14, Brînzan Alexandru5, Makaev Fliur12
 
1 Institute of Chemistry,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
3 Institute of Applied Physics,
4 Practical Scientific Institute of Horticulture and Food Technology,
5 Institute of Biology Bucharest, Romanian Academy
 
Disponibil în IBN: 17 martie 2022


Rezumat

In this work methods to obtain complexes from βcyclodextrin and dehydroabietic acid with chromenol-triazol hybrid with the sizes limits of approximately 0.1-250 μm are reported. Kneading, co-evaporation and co-precipitation as an example for preparing the inclusion complexes loaded with biologically active compounds. In vitro dissolution studies of the synthesized compounds in phosphate buffer (pH = 6.8) showed an improved dissolution rate of chromenol-triazol hybrid in the inclusion complexes compared to the free form. It has been found that β-cyclodextrin microparticulate systems loaded with dehydroabietic acid and chromenol-triazol hybrid are showed good antibacterial and antifungal activity.