Bactericidal and bacteriostatic activity of iron(iii) complexes with schiff-based ligands on staphylococcus aureus, escherichia coli and candida albicans cultures
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54.057:[546.723+541.12] (1)
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DANILESCU, Olga, COCU, Maria, BULHAK, Ion. Bactericidal and bacteriostatic activity of iron(iii) complexes with schiff-based ligands on staphylococcus aureus, escherichia coli and candida albicans cultures . In: Ecological and environmental chemistry : - 2022, Ed. 7, 3-4 martie 2022, Chișinău. Chisinau: Centrul Editorial-Poligrafic al USM, 2022, Ediția 7, Vol.1, p. 57. ISBN 978-9975-159-07-4.. 10.19261/eec.2022.v1
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Ecological and environmental chemistry
Ediția 7, Vol.1, 2022
Conferința "Ecological and environmental chemistry 2022"
7, Chișinău, Moldova, 3-4 martie 2022

Bactericidal and bacteriostatic activity of iron(iii) complexes with schiff-based ligands on staphylococcus aureus, escherichia coli and candida albicans cultures

CZU: 54.057:[546.723+541.12]

Pag. 57-57

Danilescu Olga12, Cocu Maria1, Bulhak Ion1
 
1 Institute of Chemistry,
2 State Agrarian University of Moldova
 
Proiecte:
 
Disponibil în IBN: 3 martie 2022


Rezumat

The pathogenic bacteria S. aureus and E. coli are the main cause of community and hospital-acquired bacteremia. C. albicans is the most common fungal pathogen of humans. It is known that, the substances with bacteriostatic and bactericidal effect significantly influence the level of synthesis and elimination of antioxidant enzymes in pathogens. In order to identify compounds with antimicrobial properties, three coordination compounds of iron(III): [Fe(H2L1)(H2O)2](NO3)3∙1.5H2O (1), [Fe(H2L2)(H2O)2](NO3)3∙5H2O (2) and [Fe(H2L3)(H2O)2](NO3)3∙2.5H2O (3) (where H2L1=2,6-diacetylpyridine bis(isonicotinoylhidrazone), H2L2=2,6-diacetylpyridine bis(nicotinoylhidrazone) and H2L3=2,6-diacetylpyridine bis(picolinoylhidrazone)) were tested for bactericidal and bacteriostatic properties against bacteria E. coli and S. aureus, as well as yeast-like fungi C. albicans. The antimicrobial effect was determined by counting the colony forming units (CFU) resistant to the action of analysed compounds. This method allows the kinetic study of the compound action on microbial cultures and determination of the time in which the complex manifests bactericidal properties. The obtained data are reflected in Figure. (a) (b) I Figure. Colony-forming units of E. coli (a), S. aureus (b), C. albicans (c) after exposure to complex 1 (blue), 2 (red), 3 (green) and control, without treatment (violet) The tested compounds showed a pronounced activity on E. coli from the first minutes of contact, showing a decrease to zero of the CFU number. Thus, for complex 1, the bactericidal effect was observed after 10 minutes of contact, for compound 2 – after 240 minutes, and for compound 3 it was observed only after 24 hours, when a significant decrease of the number of E. coli colonies compared to the control sample was observed (Figure, a). A special behaviour was found in the case of gram-negative bacteria S. aureus, which showed resistance to all complexes during the first 60 min, after which there was a sudden decrease in the number of colonies in the presence of complexes 1 and 3, and after 24 hours the bacterial colonies were absent in all samples (Figure, b). The results of microbiological tests showed the lack of antifungal activity of analysed complexes against C. albicans.