Spirulina biomass is used in the pharmaceutical, food and cosmetic industries. One of the conditions for keeping the microalgae and cyanobacteria biomass is the maximum humidity of 10%. The main objectives of drying the algae biomass are to maintain the biologically active content, to reduce the storage volume, to extend the shelf life of the products for further storage and processing. Microwave drying is considered to be less harmful to the environment and humans. The purpose of this study was to analyze the effects of microwave drying techniques on the biochemical composition of dry biomass. Two drying techniques have been studied. In order to identify the best drying method, microwave drying and combined drying method were studied. Better drying parameters were identified based on the proteins and fats content. The better results (proteins concentration – 66% and lipids content – 4,2% biomass) presented by samples microwave at 525W power (40% of microwave power) simultaneous with forced convection at 40°C for 7 min and microwave at 525 W power (50% of microwave power) simultaneous with forced convection at 40°C for 5 min are explained by the effect of microwaves on the Spirulina cell structure and the use simultaneous of forced convection at 40°C. Forced convection at 40°C facilitates mass transfer by reducing drying time and the effect of heat treatment on the biochemical composition of spirulina biomass. It was found that the values obtained for the native biomass perform the same nutritional value compared to that of dried biomass by combined methods. The method was tested for spirulina biomass obtained under different conditions: addition of stimulators; gold and silver pegylated nanoparticles.