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SM ISO690:2012 DRUMEA, Maria, VALICA, Vladimir, UNCU, Livia, MACAEV, Fliur. Nitrotriazon – un nou derivat nesaturat al 1,2,4 - triazolului cu acţiune antifungică. Relaţie structură – activitate. In: Revista Farmaceutică a Moldovei , 2021, nr. 1(45), pp. 8-11. ISSN 1812-5077. |
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Revista Farmaceutică a Moldovei | ||||||
Numărul 1(45) / 2021 / ISSN 1812-5077 | ||||||
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CZU: 615.282.015.11 | ||||||
Pag. 8-11 | ||||||
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Rezumat | ||||||
Fungal infections are an important chapter of infectious pathology, their incidence increasing considerably due to the widespread use of antibiotics, cytostatics and immunosuppressants. The study of the structure-activity relationship showed that the presence of 2,4-Cl-C6H4 as R1 substituent and 4-NO2-C6H4 as R2 substituent is beneficial for antifungal activity. Nitrotriazon also possesses antibacterial activity, so the 1,2,4-triazole portion can influence physicochemical parameters, such as hydrogen binding, fat solubility, polarity, can influence pharmacodynamics, pharmacokinetics and toxicity. 1,2,4-Triazoles act as pharmacophores by interacting with high affinity biological receptors due to their dipole character, hydrogen binding capacity, rigidity and solubility. Hybridization of 1,2,4-triazole derivatives with other pharmacophores has a high potential to develop new drugs. |
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Cuvinte-cheie Nitrotriazon, 1, 2, 4-triazole, antifungal, structure-activity, Nitrotriazon, 1, 2, 4-triazol, antifungic, structură– activitate |
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