In this study, the author intends to investigate the possible threats that affect the national security of the Republic of Moldova in the context of the Russian Federation’s ignorance of the state neutrality status, as explained by the delay in the process of political Regulation of the Transnistrian conflict, caused by the illegal existence of Russian military forces, funding of illegitimate institutions and separatist military structures on the left bank of the Dniester, including providing weapons and military equipment. Looking into these issues, the author particularly stresses that the process of strengthening the stability and security of a vulnerable state on the inside is painstaking and requires efforts both from state institutions, the whole society and international support. In this regard, the Republic of Moldova has undertaken to deepen its relations with the European Union by signing the Association Agreement in June 2014, which provides inter alia for the enhancement of forms of cooperation focused on common interests in the field of security promotion, defense cooperation and crisis management. By this, Moldova has accepted the challenges of aligning to the standards of development of the Community, while also benefiting from the support on behalf of development partners in a variety of domains: political, economic, social, etc. In conclusion, the author notes that in the course of cooperation, it is relevant for the European Union to ensure its security. Thus, the national interests of the Republic of Moldova in relation to certain risks and threats to national security converge with those of the Union. The European Union is politically and financially supportive of the actions that are undertaken to clarify them, but the institutions of the Moldovan State are exclusively responsible for the results of these actions/inactions.