There are variety of biologically active substances obtained from the R,R-(+)-tartaric acid which shows the antimicrobials[1] and antifungicals[2][3] properties, that encourages our research in this direction. Previous studies of chiral bis-hydrazones of (4-R,5-R)-2-aryl-1,3-dioxolane-4,5-dicarboxylic acids show selective bactericidal and fungicidal properties (1)[4]. For these reasons, is important the synthesis of new tetra-hydrazones which contains two dioxolane cycles (2c) thus making possible duplication of bioactive groups. The esters (2a) are obtained by condensation (R,R)-2,3-bis(O-trimethylsilyl)tartrate with aromatic dialdehyde[5]. The next stage is to obtain tetra-hydrazides (2b) by treatment of esters (2a) with hydrazine. The last step is condensation of tetrahydrazides (2b) with aromatic dialdehydes. The structures of compounds obtained were confirmed by IR, 1H-NMR and 13C-NMR spectra.