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SM ISO690:2012 PODGORNÎI, Ana, VALICA, Vladimir, POGREBNOI, Serghei, LUPAŞCU, Lucian, MACAEV, Fliur. Activitatea antifungică a fenoxitiazolcloralului. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 677. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 677-677 | ||||||
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Background. Fungal susceptibility is an important criteria in design of new antimycotic drugs. The parameters of susceptibility are the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MCF). Objective of the study. Susceptibility testing of Aspergillus fumigatus (A.fum.), Aspergillus versicolor (A.v.) and Candida albicans (C.alb.) to phenoxythiazolcloralum (MF10). Material and Methods. Aspergillus and Candida species; ketoconazole standard (st.); bifonazole (st); nystatin (st); MF-10 (for analysis); b-cyclodextrine - MF-10 complex (βCD:MF-10 ). NCCLS M27 methodology to C.alb. and NCCLS M38 – to A.fum and A.v. Results. Compared to ketoconazole (st), MIC of MF-10 is 18,4% less on A.fum and A.v. cultures; MCF 34,04% less (A.fum.) and 3,12% less(A.v.). MIC is 33% less and MFC- 3% less than bifonazole (st) on A.fum și A.v culture. Microbiological tests on C.alb. demonnstrated that MF-10 is 25% more active than nystatin (st.), and βCD:MF-10 complex (1:1)- by 56.25%. Conclusion. According to the obtained MIC and MCF values, MF-10 and βCD:MF-10 (1:1) have better antimycotic activity than standards. These findings will be used in the design of new antimycotic local drugs. |
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Cuvinte-cheie Phenoxythazolchloral, Phenoxythazolchloral - b-cyclodextrine complex, fenoxitiazolcloral complex fenoxitiazolcloral -β-ciclodextrine (1:1) |
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