Synthesis, characterization, and biological activity of novel 3d metal coordination compounds with 2-acetylpyridine N4-allyl-S-methylisothiosemicarbazone
Закрыть
Conţinutul numărului revistei
Articolul precedent
Articolul urmator
465 0
SM ISO690:2012
GRAUR, Vasilii О., USATAIA, Irina, BOUROSH, Pavlina, KRAVTSOV, Victor, GARBUZ, Olga, HUREAU, Christelle, GULYA, Aurelian. Synthesis, characterization, and biological activity of novel 3d metal coordination compounds with 2-acetylpyridine N4-allyl-S-methylisothiosemicarbazone. In: Applied Organometallic Chemistry, 2021, vol. 35, p. 0. ISSN 0268-2605. DOI: https://doi.org/10.1002/aoc.6172
EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core
Applied Organometallic Chemistry
Volumul 35 / 2021 / ISSN 0268-2605 /ISSNe 1099-0739

Synthesis, characterization, and biological activity of novel 3d metal coordination compounds with 2-acetylpyridine N4-allyl-S-methylisothiosemicarbazone

DOI: https://doi.org/10.1002/aoc.6172

Pag. 0-0

Graur Vasilii О.1, Usataia Irina1, Bourosh Pavlina2, Kravtsov Victor2, Garbuz Olga1, Hureau Christelle3, Gulya Aurelian1
 
1 Moldova State University,
2 Institute of Applied Physics,
3 Laboratoire de Chimie de Coordination du CNRS, Toulouse
 
Disponibil în IBN: 30 martie 2021


Rezumat

New zinc(II), copper(II), nickel(II), iron(III), and cobalt(III) coordination compounds, [Zn(HL)I2] (1), [Cu(HL)Cl2] (2), [Cu(HL)Br2] (3), {[Cu(HL)NO3]NO3}n (4), [Ni(HL)2](NO3)2 (5), [Fe(L)2]NO3(6), [Co(L)2]NO3 (7), and [Co(L)2]Cl·H2O (8), were obtained with 2-acetylpyridine N4-allyl-S-methylisothiosemicarbazone (HL). The isothiosemicarbazone proligand was characterized by nuclear magnetic resonance (NMR) (1H and 13C), infrared (IR) spectroscopy, and X-ray diffraction. All the coordination compounds were characterized by elemental analysis, IR, UV–Vis spectroscopy, molar conductivity, and magnetic susceptibility measurements. Single-crystal X-ray diffraction analysis elucidated the structure of the cationic form of the proligand in the salt [H2L]I and compounds 1–4 and 8 and demonstrated an unusual way of coordination through methylated sulfur atom in 1 and 3. Nevertheless, the electron paramagnetic resonance (EPR) and UV–Vis investigations showed that this way of coordination quickly changes upon dissolution of coordination compounds in dimethyl sulfoxide (DMSO). The antiproliferative properties of these compounds towards human cervical epithelial HeLa, human epithelial pancreatic adenocarcinoma BxPC-3, human muscle rhabdomyosarcoma spindle, large multinucleated RD cancer cell lines, and normal kidney epithelial MDCK cell line have been investigated. Copper coordination compounds (2–4) show promising anticancer activity with high selectivity (selectivity index [SI] = 10–18) towards BxPC-3 cell line. They also possess significant antibacterial and antifungal activity, which is useful for cancer treatment. 

Cuvinte-cheie
antiproliferative activity, cancer cells, coordination compounds, crystal structure, isothiosemicarbazones