| Articolul precedent |
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| Ultima descărcare din IBN: 2024-01-29 14:31 |
 SM ISO690:2012GULYA, Aurelian, RUSNAC, Roman, RUSNAC, Anna, TSAPKOV, Victor I.. Ethyl-4-{2-[(pyridin-2-ylmethylidene) hydrazinocarbothioyl] amino benzoate monohydrate exhibiting properties of human myeloid leukemia HL-60 cell proliferation inhibitor. In: Cercetări şi inovaţii în viziunea tinerilor cercetători: “Cadet INOVA’20”, 26-28 martie 2020, Sibiu. Sibiu, România: Editura Academiei Forţelor Terestre „Nicolae Bălcescu”, 2020, Nr.5, p. 286. ISSN ISSN 2501-3157 ISSN-L 2501-3157. |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
| Cercetări şi inovaţii în viziunea tinerilor cercetători Nr.5, 2020 |
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Conferința "Cercetări şi inovaţii în viziunea tinerilor cercetători" Sibiu, Romania, 26-28 martie 2020 | ||||||
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The invention relates to chemistry and medicine, namely to a novel biologically active organic compound of the thiosemicarbazone class and may find application in medicine for the prophylaxis and treatment of human myeloid leukemia. The compound ethyl-4-{2 [(pyridin-2-ylmethylidene)hydrazinecarbothioyl]amino}benzoate is a molecular inhibitor of the multiplication of HL-60 cells of human myeloid leukemia, is active at concentrations 10-5-10-7 mol/L and has a semi maximal inhibition concentration (IC50) equal to 0.1 μmol/L, which is 10 times more effective than doxorubicin drug used in medicine in chemotherapeutic treatment. |
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