Investigations are based on determination of changes of intestinal microbian flora of indices to chickens and some biochemical indexes under the action of biomass of streptomycetes. For this was obtained the biomass of some strains of streptomycetes which was administered in the daily ration of chicks. For proposed scheme, at different periods after administration of biomass was harvested from the intestines of chicks lavages, blood and serum samples for serological, microbiological and biochemical investigations. As a result  was established that in the experimental groups of chickens which was feed with  biomass of streptomycetes, were higher the total blood proteins,  body weight  and the intestinal microflora was composed of symbiotic microorganisms bowel without taking the antibiotics for prophylaxis  of bacterial intestinal infections.