We report the results of the effect of uniaxial strain on the thermopower (S) and electric resistance (R) of glass-coated individual Bi wires with diameters of 0.1 – 2.0 μm. By combining thermal annealing, uniaxial deformation, and magnetic field, we have succeeded in conducting with thermoelectric parameters. A fairly high value of thermoelectric power factor (S2/ρ = 57 μW/cm⋅K2) was found in a temperature range of 77–150 K at a strain value of 2.5 %. At low temperatures, the thermopower dependences on strain S(ε) exhibit a non-monotonous behavior inherent in thinner wires, where S is dominated by diffusion transport mechanism of holes. Hole-dominated transport can be transformed into electron-dominated transport through a smooth manipulation with the phonon spectrum and Fermi surface by applying a uniaxial strain. The transport properties of Bi wires are examined in the light of a strain-induced Electronic Topological Transition (ETT).