The use of medicinal plants in treating or preventing different complaints has invigorated interest in folk medicine practices. Our studies started from the necessity of valuing some of the indigenous plant species, insufficiently studied at national and international level. Lamium album L. (Lamiaceae family) is a medicinal plant widely used in traditional and folk medicine as potent astringent and anti-hemorrhagic. L. album is an edible plant used also as a component of food supplements, because of its pharmacological effects.The plant also possess cholagogue, depurative, diuretic, expectorant, hypnotic, pectoral, sedative, tonic and vasoconstrictor properties. The toxic, anti-proliferative, and free radical scavenging activities of methanol and ethyl acetate extracts of this plant were demonstrated by detailed investigations (Paduch R. et al, 2008). Current studies (Topouzova-Hristova T. et al., 2012) showed also a promising anticancer effect of extracts from L. album L. The present researchstarted in 2013 aiming to assess and characterize the natural habitats and to obtain scientific out comeand practical requirements for cultivation. Habitat type is given according to NATURA 2000 (Interpretation Manual of EU Habitats, 2003, Directive 92/43/EEC). Studies for plant cultivation were carried out in the Experimental subdivision of the collection of medicinal plants in the Botanical Garden of ASM. Phytochemical analyses were carried out at Center of Biological Sciences „Stejarul”, Piatra Neamț, Romania. Lamium album L. is a native plant distributed naturally throughout Republic of Moldova except the southern parts. We conducted field studies at three forested sites: Landscape reserve “Saharna” (N 47° 41’ 40”, E 28° 57’ 51”), Rezina district; South of Soroca town, protected area “BekirovYar” (N 48° 08’ 05”, E 28° 18’ 37”) and north of Kamenka town, Transdniester region (N 48° 02’ 13”, E 28° 40’ 48”). The habitat for L. album was categorized as Euro-Siberian steppic woods with Quercus sp. (Xero-thermophile oak woods of the plains of south-eastern Europe) with code number 91IO. Plant communities are characterized by European continental species. Floristic composition: edifying species: Q. robur exclusively or with Quercus petraea, Fraxinus excelsior, Cerasus avium. Other important species: Acer tataricum, Malus sylvestris, Convallaria majalis, Geumurbanum, Glecoma hirsuta, Nepetacataria, Phlomis tuberosa etc. Preliminary phytochemical study conducted on L. album aimed to evaluate the content of polyphenols from plants (herba) in flowering phase (June-July and August-September, 2013). By spectrophotometry method (spectrophotometer system: Jenway 6300 Visible Spectrophotometer) was examined the content of polyphenolic compounds in methanol extracts (MeOH). The following values were registered on analysed samples: 0.623-0.713 for total polyphenols (gallic acid equiv. g/100 g d. w.), 0.562-0.609 for polyphenolcarboxylic acids (rosmarinic acid equiv. g/100 g d. w.) and 0.171-0.179 for flavonoids (rutoside acid equiv. g/100 g d. w.). Compared with plants flowering in June-July, the plants bloomed in August-September registered a decrease of about 50% of the content of all three classes of biologically active principles. Other step was selection of vegetal materialand creating experimental fields in the Botanical Garden for observing the acclimatization and reproductive behavior in ex-situ conditions. It was revealed that under the condition of cultivation the rhythm of seasonal development of L. album was generally the same as in natural habitats. Its growth was excellent and successfully passed all phenological phases, attaining the generative period in the first vegetative season. The work was supported by the Bilateral Collaboration Project ASM-ANCS “Assessment and characterization of genetic resources of Lamiaceae species with anti-inflammatory potential in order of their in situ and ex situ conservation” (financing contract Nr. 04/RoA/2013).