Novel 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity
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BALAN, Greta; , ; , ; , ; CHUMAKOV, Yurii; , ; , ; , ; ,. Novel 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity. In: Applied Organometallic Chemistry. 2020, nr. 3(34), p. 0. ISSN 0268-2605.
10.1002/aoc.5423
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Applied Organometallic Chemistry
Numărul 3(34) / 2020 / ISSN 0268-2605

Novel 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone and Zn(II), Cu(II), Ni(II) and Co(III) complexes: Synthesis, characterization, crystal structure, antioxidant, antimicrobial and antiproliferative activity


DOI: 10.1002/aoc.5423
Pag. 0-0

Balan Greta1, 1, 2, 2, Chumakov Yurii34, 3, 1, 2, 5
 
1 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
2 State University of Moldova,
3 Institute of Applied Physics,
4 Gebze Technical University,
5 University of Medicine and Pharmacy “Carol Davilla”, Bucharest
 
Disponibil în IBN: 12 martie 2020


Rezumat

New zinc (II), copper (II), nickel (II) and cobalt (III) complexes, [Zn (HL)2]I2 (1), [Cu (HL)Cl2] (2), [Cu (HL)Br2] (3), [Cu (HL)(H2O)2](ClO4)2 (4), [Ni (HL)2]I2·H2O (5), [Co(L)2]Cl (6), [Co(L)2]NO3 (7), [Co(L)2]I·[Co(L)2](I3) (8) were obtained with 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone (HL). The isothiosemicarbazone ligand was characterized by NMR (1H and 13C), IR spectroscopy and X-ray diffraction. All the complexes were characterized by elemental analysis, IR, UV–Vis, ESI-MS spectroscopy, molar conductivity, magnetic susceptibility measurements. X-ray diffraction analysis on the monocrystal and powder elucidated the structure of the complexes 1, 5, 7 and 8. The ligand and the complexes were tested for their antioxidant and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Candida albicans. Also, the antiproliferative properties of these compounds on human leukemia HL-60, human cervical epithelial HeLa, human epithelial pancreatic adenocarcinoma BxPC-3, human muscle rhabdomyosarcoma spindle, large multinucleated RD cells and normal MDCK cells have been investigated. The nickel complex 5 and cobalt complexes 6, 7 showed promising antiproliferative activity and low toxicity. © 2019 The Authors. Applied Organometallic Chemistry published by John Wiley

Cuvinte-cheie
Antimicrobial activity, antioxidant activity, antiproliferative activity, complexes, crystal structure