Automatic amperometric titration method for quantitative determination of zinc oxide in ointments
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2020-05-26 08:52
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615.454.1.074:546.47-31+543.553.4 (1)
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OPREA, Vasile; VALICA, Vladimir; CHEPTĂNARU, Constantin; NISTORICA, Mihai; OPREA, Sergiu; MOVILĂ, Liviu. Automatic amperometric titration method for quantitative determination of zinc oxide in ointments. In: Moldovan Medical Journal. 2020, nr. 1(63), pp. 13-18. ISSN 2537-6373.
10.5281/zenodo.3685650
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Moldovan Medical Journal
Numărul 1(63) / 2020 / ISSN 2537-6373 /ISSNe 2537-6381

Automatic amperometric titration method for quantitative determination of zinc oxide in ointments


CZU: 615.454.1.074:546.47-31+543.553.4
DOI: 10.5281/zenodo.3685650
Pag. 13-18

Oprea Vasile1, Valica Vladimir1, Cheptănaru Constantin1, Nistorica Mihai12, Oprea Sergiu3, Movilă Liviu12
 
1 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
2 Medicines and Medical Devices Agency,
3 Academy of Economic Studies of Moldova
 
Disponibil în IBN: 11 martie 2020


Rezumat

Background: Zinc is an important trace mineral in human body, therefore development of new methods for zinc determination in drugs is an actual task. Material and methods: Assay of standard solutions of zinc ions and solutions of ointments to be analyzed was performed automatically using the titrator TITRION, which recorded, then displayed on the screen each amperometric titration curve. The titration curves had a sudden break in the current intensity at the equivalence point, caused by anodic oxidation of the titrant and cathodic reduction of H+ at pH 3 – 4. The stoichiometry of Zn2+ ion sedimentation reaction with [Fe(CN)6]4- ions was studied and confirmed in the presence of the background electrolyte and the ZnO calculation formulas in the analyzed ointments were deduced. Results: Two different ointment masses were weighed for the Zoxitin ointment and the separate calculation results were 0.4172±0.0051 g/g and 0.4212±0.0051 g/g of ointment, and in the zinc oxide ointment ω(ZnO) was 10.208±0.078 %.These results were compared with the results of ZnO analysis in ointment by the classical complexometric titration method. For the Zoxitin ointment m(ZnO) was 0.4223±0.007 g/g of ointment, and for the ointment with ZnO ω(ZnO) was 10.18±0.11%. Conclusions: An automatic amperometric titration method was developed to quantify ZnO in ointments. The method is based on the sedimentation reaction of zinc ions with potassium ferrocyanide solution in presence of acetate buffer solution as background electrolyte.

Cuvinte-cheie
automatic amperometric titration, zinc oxide, quantitative determination of Zn