Mesenchymal stem cells proliferation and remote manipulation upon exposure to magnetic semiconductor nanoparticles

Braniste Tudor; Cobzac Vitalie; Ababii Polina; Pleşco (Jin) Irina; Raevsky Simion; Didencu Alexandru; Manyuk Mihail; Nacu Viorel; Ababiy Ivan; Tiginyanu Ion

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BRANISTE, Tudor, COBZAC, Vitalie, ABABII, Polina, PLEŞCO (JIN), Irina, RAEVSKY, Simion, DIDENCU, Alexandru, MANYUK, Mihail, NACU, Viorel, ABABIY, Ivan, TIGINYANU, Ion. Mesenchymal stem cells proliferation and remote manipulation upon exposure to magnetic semiconductor nanoparticles. In: Biotechnology Reports, 2020, vol. 25, p. 0. ISSN 2215-017X. DOI: https://doi.org/10.1016/j.btre.2020.e00435

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Biotechnology Reports

Volumul 25 / 2020 / ISSN 2215-017X /ISSNe 2215-017X

Mesenchymal stem cells proliferation and remote manipulation upon exposure to magnetic semiconductor nanoparticles

DOI:https://doi.org/10.1016/j.btre.2020.e00435

CZU: [538.9+544+621.38]:611.018.46

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Braniste Tudor¹, Cobzac Vitalie², Ababii Polina², Pleşco (Jin) Irina¹, Raevsky Simion³, Didencu Alexandru², Manyuk Mihail², Nacu Viorel², Ababiy Ivan², Tiginyanu Ion¹⁴

¹ Technical University of Moldova,
² ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
³ Moldova State University,
⁴ Academy of Sciences of Moldova

Proiecte:

Menționat în lucrare: 19.80012.50.03A Elaborarea suprafețelor cu grad controlat de hidrofobie datorită nano-microstructurii

Menționat în lucrare: 20.80009.5007.20 Nanoarhitecturi în bază de GaN și matrici tridimensionale din materiale biologice pentru aplicații în microfluidică și inginerie tisulară

Menționat în lucrare: GA 810652

Promoting smart specialization at the Technical University of Moldova by developing the field of Novel Nanomaterials for BioMedical Applications through excellence in research and twinning

GA 810652

Promoting smart specialization at the Technical University of Moldova by developing the field of Novel Nanomaterials for BioMedical Applications through excellence in research and twinning

Disponibil în IBN: 6 martie 2020

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In this paper, we report on spatial redistribution of bone marrow mesenchymal stem cells loaded with magnetic nanoparticles under the influence of continuously applied magnetic field. Semiconductor nanoparticles were synthesized by epitaxial growth of a GaN thin layer on magnetic sacrificial core consisting of ZnFe₂O₄ nanoparticles. Different quantities of nanoparticles were incubated in vitro with mesenchymal stem cells. High density of nanoparticles (50 μg/ml) leads to a decrease in the number of cells during incubation, while the density of nanoparticles as low as 10 μg/ml is enough to drag cells in culture and rearrange them according to the spatial distribution of the magnetic field intensity.

Cuvinte-cheie
Cells guiding, Gallium nitride, mesenchymal stem cells, nanoparticles

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