Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model
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ZAKROYEVA, Alla; LESNYAK, Olga; CAZAC, Victor; GROPPA, Liliana; RUSSU, Eugen; CHIŞLARI, Lia; ROTARU, Larisa; JOHANSSON, Helena; HARVEY, Nicholas C.W.; MCCLOSKEY , Eugene V.; LORENTZON, Mattias; KANIS, John A.. Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model. In: Archives of Osteoporosis. 2020, nr. 1(15), p. 0. ISSN 1862-3522.
10.1007/s11657-019-0669-z
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Archives of Osteoporosis
Numărul 1(15) / 2020 / ISSN 1862-3522 /ISSNe 1862-3514

Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model


DOI: 10.1007/s11657-019-0669-z
Pag. 0-0

Zakroyeva Alla1, Lesnyak Olga2, Cazac Victor3, Groppa Liliana3, Russu Eugen3, Chişlari Lia3, Rotaru Larisa3, Johansson Helena4, Harvey Nicholas C.W.5, McCloskey Eugene V.6, Lorentzon Mattias7, Kanis John A.46
 
1 Ural State Medical University,
2 Universitatea de Stat de Medicină Nord-Vest I.I. Mecinikov,
3 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
4 Catholic University of Australia, Melbourne, Australia,
5 University of Southampton,
6 University of Sheffield,
7 University of Gothenburg
 
Disponibil în IBN: 17 februarie 2020


Rezumat

Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment. Objective: This paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX® tool. Methods: We carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country’s population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models. Results: The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania). Conclusion: The FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment. 

Cuvinte-cheie
epidemiology, Fracture probability, FRAX, Hip fracture