The purpose of this study was to examinethe evolution of clinical, biochemical and immunological parameters in patients with chronic viral hepatitis and liver cirrhosis under the infl uence of treatment with Imuheptin and Imupurin. After 3 months of treatment was found complete regression or decrease of clinical signs and syndroms: dyspepsic and astenovegetativ syndroms, hepatomegaly, splenomegaly, artralgy. The positive evolution of clinical signs was confi rmed by results of laboratory investigations. Decrease of ALT and AST activity in all monitored patients and decrease of thymol test level were found. It was found immunomodulating effect: increase of the CD4+- and CD3+-lymphocytes and decrease of the CD20+-lymphocytes and CIC. During the study all patients established good tolerability of the administered medication.

Studiul a fost întreprins cu scopul studierii evoluţiei parametrilor clinico-biochimici şi imunologici la bolnavii cu hepatite virale cronice şi ciroză hepatică sub infl uenţa tratamentului cu Imupurin şi Imuheptin. După 3 luni de tratament, s-a constatat regresarea totală sau diminuarea sindroаmelor şi simptomelor clinice: dispepsic, asteno-vegetativ, hepatomegalia, splenomegalia, artralgia. Evoluţia pozitivă a simptomaticii clinice a fost confi rmată prin rezultatele investigaţiilor de laborator. S-a constatat diminuarea activităţii AlATşi AsAt la toţi pacienţii supravegheaţi şi reducerea nivelului probei cu timol. A fost constatat efectul imunomodulator – creşterea număruluiCD4+- şi CD3+limfocitelor şi micşorarea numărului CD20+-limfocitelor şi a CIC. Pe parcursul studiului, toţi pacienţii au manifestat toleranţă bună la terapia administrată.