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SM ISO690:2012 PELTEC, Angela. Nonalcoholic fatty liver disease: blame the gut microbiota – the original pathogenetic mechanisms? In: Sănătate Publică, Economie şi Management în Medicină , 2013, nr. 5(50), pp. 141-146. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | |||||
Numărul 5(50) / 2013 / ISSN 1729-8687 /ISSNe 2587-3873 | |||||
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Pag. 141-146 | |||||
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In the past decade, a growing body of research functionally links the intestinal microbiota with the development of steatosis and with the progression to NASH. The composition of the microbiota directly influences calorie extraction, body fat composition, and body weight. Microbiota dysbiosis can promote NASH both by decreasing choline levels and increasing toxic methylamines. Bile acids may be further crucial factors linking gut microbiome composition, dysmetabolism and liver damage in NAFLD. Intestinal microfl ora produces a number of potentially hepatotoxic compounds such as ethanol, phenols, ammonia, which generate of reactive oxygen species and consequently liver infl ammation. |
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Cuvinte-cheie non-alcoholic fatty liver disease, gut microbiota, gut-liver axis, неалкогольный стеатоз печени, кишечная микрофлора, кишечно-печеночная ось |
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