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SM ISO690:2012 DUMBRAVA, Vlada-Tatiana, LUPAŞCO, Iulianna, TARAN, Natalia, TOFAN-SCUTARU, Liudmila, IONAŞCU, Marina, COJUHARI, Maria, DELI, M.. Evaluarea tratamentului antiviral la pacienţii cu ciroze hepatice de etiologie virală C şi D. In: Sănătate Publică, Economie şi Management în Medicină , 2013, nr. 5(50), pp. 118-122. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 5(50) / 2013 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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Pag. 118-122 | ||||||
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Study group: 49 patients, 17 (34.69%) women and 32 (65.31%) men with hepatic viral cirrhosis, Child-Pugh stage A: 24 – D viral etiology and 25 – viral C genesis. Average age: 44.41 ± 0.4 years in women and 47.59 ± 0.6 years in men. Purpose: evaluation of the antiviral treatment response at 12 weeks and 24 weeks after initiation and assessment of laboratory results during antiviral therapy in patients with liver cirrhosis C and D. In patients with liver cirrhosis HDV, treated with Peg-INF undetectable viral load was achieved at 12 weeks in 28% cases and after 24 weeks of treatment it is observed in 25% cases. In the group of patients with liver cirrhosis HCV, treated with Peg-INF + Ribabirină – 12 weeks of treatment – 75% of patients responded positively: 48% achieved complete EVR and 24% – EVR part. Evaluation of patients at 24 weeks of treatment show a positive virologic response in 56% cases. In patients with liver cirrhosis HCV and HDV, where the virological response was absent, more severe and early complications of antiviral therapy are observed: the blood count shows anemia, major leukopenia and thrombocytopenia. |
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Cuvinte-cheie liver cirrhosis, antiviral treatment, sustained virological response, unidentifi ed viremia, цирроз печени, противовирусное лечение, вирусологический ответ, авиремия |
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