Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
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SM ISO690:2012 BUGAI, Rodica. Impactul unor factori de risc genetici în pancreatita cronică. In: Sănătate Publică, Economie şi Management în Medicină , 2013, nr. 5(50), pp. 17-20. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 5(50) / 2013 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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Pag. 17-20 | ||||||
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Recent breakthroughs in understanding the etiology and pathways toward pancreatic diseases, and especially acute and chronic pancreatitis (CP), reveal that specifi c variation in the genomic DNA sequence of individuals strongly infl uence their susceptibility to pancreatitis, the severity and nature of the infl ammatory process, and the likelihood of various complications. The purpose of the study was to assess the impact of genetic risk factors in the development of CP in the Moldovan population and included 25patients with relapsed and pseudotumoral CP and 30 healthy people with PRSS1and SPINK1 gene polymorphism determination. Venous blood being used as a sample, using the method of polymerase chain reaction (PCR) and corresponding primers, at the Academy of Sciences Institute of Genetics. The high frequency of mutant alleles in the gene that encodes PRSS1cationic trypsinogen and the gene of the pancreatic PSTI/ SPINK1 trypsin inhibitor detected in patients with CP with recurrent and pseudotumoral form vs. healthy individuals indicates the importance of these mutations in the development of the disease and requires prospective studies. The assessment of genetic risk factors and their interaction with other exo- and endogenous factors would enable the prevention, early diagnosis and reduction of risks in CP. |
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Cuvinte-cheie chronic pancreatitis, PRSS1 mutations, SPINK1 mutations, хронический панкреатит, мутации PRSS, мутации PSTI/SPINK1 |
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