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SM ISO690:2012 MACAGONOVA, Olga. Modelarea pemfigusului vulgar pe animale experimentale. In: Sănătate Publică, Economie şi Management în Medicină , 2013, nr. 4(49), pp. 70-73. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 4(49) / 2013 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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Pag. 70-73 | ||||||
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Pemphigus vulgaris is a severe disease that varies depending on clinical and epidemiological profi le in different regions of the world. The bullous and ulcerativeerosive lesions of skin and the mucous membranes are the hallmarks of the disease. Corticosteroids, immunosuppressive agents have remained the pillar of therapy in patients with pemphigus vulgaris in spite of adverse effects. Under conditions of current therapy, the prognosis of desease depends primarily on patient response to corticosteroids and the complications that they induce long-term administration. Over several decades animals have been used as models to study human diseases. In essence, the small laboratory animals, particularl, mice are taken as an yardstick. In order to develop new therapeutic strategies in pemphigus vulgaris we present the dates from the literature regarding the modeling of pemphigus vulgaris in the experimental animals to study the disease evolution and the identifi cation of some new methods of the treatment before applying them in humans. We here review some mouse models that allow for investigation of one or more steps of pathogenic events occurring in pemphigus vulgaris. Analysis of data from the literature on these models that reproduce the fi ndings in pacients with autoimmune bullous skin diseases, offers the possibility to identify the future directions for research and to develop new experimental approach that opens new perspectives in the development of innovative therapeutic methods for these patients. |
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Cuvinte-cheie pemphigus vulgaris, autoimmune disease, modeling, mouse, evaluation, systemic degenerative lesions, вульгарная пузырчатка, аутоиммунное заболевание, моделирование, мышь, оценка, системные дегенеративные поражения |
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