Telomeres and Aging
Închide
Articolul precedent
Articolul urmator
890 22
Ultima descărcare din IBN:
2023-10-12 18:22
SM ISO690:2012
HINDI, Nadine, NAFFAR, Said, SIDORENKO, Ludmila. Telomeres and Aging. In: NANO-2019: Limits of Nanoscience and Nanotechnologies, Ed. 2019, 24-27 septembrie 2019, Chişinău. Chișinău, Republica Moldova: 2019, p. 56.
EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core
NANO-2019: Limits of Nanoscience and Nanotechnologies 2019
Conferința "SPINTECH Summer school “S/F Hybrid Structures for Spintronics”"
2019, Chişinău, Moldova, 24-27 septembrie 2019

Telomeres and Aging


Pag. 56-56

Hindi Nadine, Naffar Said, Sidorenko Ludmila
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 23 ianuarie 2020


Rezumat

Telomeres and their effects on aging and health is a promising field of research because this might be the way to find a way to stop aging and elongate the lifespan of the human’s cells. The telomere are repetitive DNA sequences at the ends of all human chromosomes, In humans there are 46 chromosomes and thus 92 telomeres (one at each end). They protect the chromosomes (cap) and they separate one chromosome from another in the DNA sequence. Without telomeres the ends of the chromosomes would be repaired, leading to chromosome fusion and massive genomic instability. Also Telomeres are thought to be the “clock” that regulates how many times an individual cell can divide. Telomeres sequences shorten each time the DNA replicates. A special ribonucleoprotein enzyme called telomerase works by adding back telomeric DNA to the ends of chromosomes, for this reason the loss of telomeres that normally occurs as cells divide. Most normal cells do not have this enzyme and thus they lose telomeres with each division. Once a cell’s telomeres have reached a critically short length, that cell can no longer divide. Its structure and function begins to fail. Some cells even die. The over shorting of telomeres leads to feel and see signs of aging: The skin cells start to die which cause to fine lines and wrinkle, hair pigment cells die and the person starts to see gray , immune system cells die and the risks to get sick is higher. Also underlying some cardiovascular diseasse, Alzheimer’s disease, cancer and diabetes. Telomeres’ shortening may be an active contributor to the genetic abnormalities that trigger cancer because dysfunctional telomeres drive genome instability. Lifestyle factors such as smoking, lack of physical activity, obesity, stress, exposure to pollution, etc. can potentially increase the rate of telomere shortening, cancer risk, and pace aging. In order to delay aging and shortening telomeres, it is recommended to have a healthy lifestyle including enough movement, free breathing, good mood, control stress reactions, enough night sleep, sufficient mental concentration during planning and during actions, balanced diet. Exercise can reduce harmful lipids in organism and help mobilize waste products for faster elimination, leading to reduced oxidative stress and preservation of DNA and telomeres and may therefore reduce the pace of aging and age-associated diseases. In Conclusion, Telomeres shorten with age. Older people with shorter telomeres have three and eight times increased risk to die from heart and infectious diseases, respectively. To preserve telomeres and reduce cancer risk and pace of aging, humans may consider to eat less, include antioxidants, fiber and healthy fats (derived from avocados, fish, and nuts) in daily diet, also to stay lean, active, healthy, and stress-free through regular exercise and meditation. Taking in consideration the study of Nobel prize winner Blackburn E., shortly should be kept in mind “Telomeres listen to you, they listen to your behavior, they listen to your state of mind”.