In modern lifestyle societies stress become a phenomenon that almost everyone dealing with time to time, it is important to understand how stress can affect the human’s life and specially our health, chronic stress has been associated with the pathogenesis of many diseases including cancer. In 2019 was studied by Seladi – Schumann J. et al. central and examined human breast tumor cells implanted in mice. Researchers found an increase in the activity of receptors for stress hormones in sites where metastasis occurred. This suggests that activation of these receptors by stress hormones could play a role in metastasis. TP53 is known as gene provides instruction for making a protein called tumor protein P53. Environmental stress is a risk factor for people with a genetic predisposition to cancer, with mutations in TP53. Stress is a natural response that the body has to perceive threats but having chronic stress increases the risk for a variety of health conditions, such as developing cancer. As it creates favorable conditions when a genetic predisposition to cancer is realised in its clinical manifestation. Regarding the fact that stress can lead to the transformation of genes in oncogenes it is important to control consciously all emotions occurring in the daily life in order to reduce the chronic psychoemotional stress. Humans should control stress in their life before it starts to control the humans.