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| Articolul precedent |
| Articolul urmator |
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 805 21 |
| Ultima descărcare din IBN: 2023-09-10 03:50 |
| Căutarea după subiecte similare conform CZU |
| 542.06:547:615.1 (2) |
| Chimie practică de laborator. Chimie de preparare și experimentală (138) |
| Chimie organică (484) |
| Farmacia în general şi profesia de farmacist (184) |
 SM ISO690:2012BLAJA, Svetlana. Synthesis of new di- and tri-norlabdane compounds with 2-amino-1,3-thiazole units. In: Chemistry Journal of Moldova, 2019, nr. 2(14), pp. 72-78. ISSN 1857-1727. DOI: https://doi.org/10.19261/cjm.2019.609 |
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  Chemistry Journal of Moldova |
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| Numărul 2(14) / 2019 / ISSN 1857-1727 /ISSNe 2345-1688 | ||||||
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| DOI:https://doi.org/10.19261/cjm.2019.609 | ||||||
| CZU: 542.06:547:615.1 | ||||||
| Pag. 72-78 | ||||||
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The present paper reports the synthesis of new hybrid terpeno-heterocyclic compounds belonging to di- and tri-norlabdane series. Starting from natural labdane diterpenoide (-)-sclareol, via its intermediates 8α-hydroxy-15,16-dinorlabd-13-one and sclareolide, two di-norlabdane and three tri-norlabdane, previously unreported compounds possessing 2-amino-1,3-thiazole structural units were obtained in three and four steps, respectively, with acceptable to good overall yields. The structures of newly obtained compounds were confirmed by means of spectral IR, 1H and 13C NMR analyses. It can be assumed that the synthesized compounds possess potential biological activity due to the presence of the heterocyclic unit. Additionally, the mechanism of 2-amino-1,3-thiazole ring formation is proposed. |
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| Cuvinte-cheie synthesis, di-norlabdane, tri-norlabdane, 2-amino-1, 3-thiazole, cyclization reaction |
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