Is known that in the process of evolution currently existing microorganisms in the environment they colonized various open cavities of the human and animal organism, being considered for each genus and species, until the present as specific ecological niches. Currently, experimentally it is found that the human and animal digestive tract serves as a ecological niche to about 500 species of bacteria. According to accessible bibliographic data in most scientific papers such bacteria have the form of bacilli (for example, the genera Bifidobacterium, Lactobacillus, Bacteroides, Escherichia, Proteus, Clostridium, Eubacterium, Selenomonas et al). In the works published in the last 15 years it warns about the fact of existence in the composition of gastrointestinal bacteriocenosis and bacteria in the form of cocci, but they are in a limited quantity and mainly refers to Institute of Physiology and Sanocreatology and the Department of Microbiology, Virology and Immunology of the State University of Medicine and Pharmacy «Nicolae Testemitanu» Republic of Moldova. Therefore the purpose of the present research was to highlight bacteria in the form of cocci what can be found in the intestinal (rectal) human and animal contents, that is which are specific to their digestive tract. The researches planned to achieve the goal were carried out in several stages. Initially human and animal individuals were chosen with different health status (sanogenic and pathological); from the selected individuals monotulpins of bacteria in the form of cocci were isolated and then subjected the kind identification. The result was observed that children, piglets and calves with state health sanogenic preponderant stood out microorganisms of the genera: Streptococcus, Lactococcus, Enterococcus, Ruminococcus et al., and with the pathological - Streptococcus, Micrococcus, Diplococcus, Pneumococcus, Staphylococcus etc., being not characteristic of the healthy macroorganism. The data obtained argued recommendation for inclusion in the pharmaceutical preparations with probiotic action of streptococci monotulpins isolated only from healthy subjects that is, with the sanogenic state of the health of the body.