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Ultima descărcare din IBN: 2023-03-14 21:07 |
SM ISO690:2012 BOLDESCU, Veaceslav. Nanostructurile pe bază de ciclodextrine în tehnologia medicamentelor
. In: Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii), 2008, nr. 2(12), pp. 186-192. ISSN 1814-3237. |
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Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii) | ||||||
Numărul 2(12) / 2008 / ISSN 1814-3237 /ISSNe 1857-498X | ||||||
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Pag. 186-192 | ||||||
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Rezumat | ||||||
One of the main problems of the contemporary pharmaceutical technology is release of drugs into the environment.
Consequently, resistance of target cells towards these medicines develops. In order to reduce the amount of pharmaceuticals
released into the environment and to enhance their pharmacokinetics, the use of nanostructures on the bases of
cyclodextrins has been proposed. Cyclodextrins are cyclic torus-shaped molecules with a hydrophilic outer surface and
a hydrophobic central cavity that can accommodate a variety of drug entities. Different technologies have been designed
for drug-cyclodextrin encapsulation: physical mixture, kneading, co-precipitation, co-evaporation, lyophilization. The
efficiency of these technologies in the inclusion complexes preparation is discussed in this paper. |
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