Biopesticides are mass-produced, biologically based agents used for the control of plant pests. They are an important part of integrated pest management (IPM), which aims to use complementary methods to manage pest populations at low levels, rather than eliminate them entirely. Biopesticides are being used on increasing scales and there is considerable interest in their potential as alternatives to conventional pesticides. Biopesticides have also attracted great interest in the international research community, with a significant increase in the number of publications devoted to the subject. At Institute of Genetics, Physiology and Plant Protection are prepared the bioinsecticides for use in Republic Moldova, mostly for the control. In order to reduce the population of insect it is recommended utilization of inoffensive preparations baculoviruses highlypathogenic for the leaf-champing vermis of the Hyphantria cunea, were selected from the insect natural populations which is an efficient preparation for combating this pest in agricultural, onamental and forest biocenosis. This study aimed to highlight new agents for biological control of pest. The results of the present study revealed the larvicidal potential of baculovirusess isolates found in the larvae of H. cunea, local production of biopesticides, which will reduce the final cost of the product and will more accessible to farmer.