Biopesticides have attracted attention in pest management in recent decades, and have long been promoted as prospective alternatives to synthetic pesticides. Biopesticides have also attracted great interest in the international research community, with a significant increase in the number of publications devoted to the subject. Recently, new substances, products of the baculovirus have been reported in the literature as promising compounds for use as biopesticides, but more field research is required to assess the effects on specific pest problems under diverse cropping systems. This study investigated the potential of baculovirus isolates obtained in IGFPP in the Republic of Moldova for the control of Hyphantria cunea, a dangerous invasion pest which has quickly settled in the territory of the Republic of Moldova. This study aimed to highlight new agents for biological control of invasive pest on local baculovirus. The results of the present study revealed the larvicidal potential of baculovirus isolates found in the larvae of H.cunea, local production of biopesticides, which will reduce the final cost of the product and will be more accessible to farmers.