The synthesis of hybrid terpeno-heterocyclic compounds is a recent concern of researchers in the field of natural products. Several papers describing the synthesis and biological activity of terpenic compounds bearing diazine [1,2], carbazole [2], triazole [2,3], oxadiazoleand thiadiazole [4] units have been recently published. It should be noted that the intermediates of terpenoheterocyclic compounds often exhibit biological activity. This communication confirms this fact and presents last-minute results. We report the synthesis of new di- and trinorlabdane thiosemicarbazides 1 and 2, tetranorlabdane 2-iminothiodiazole 3 and diacyl hydrazide 4, obtained in 60%-82% yields Figure 1. The structures of compounds 1-4 were fully confirmed by 1H, 13C and 2D NMR analysis.formulaFigure. New nitrogen and sulfur containing bioactive norlabdanes. Compounds 1-4 were tested in vitro for antifungal and antibacterial activity on five strains of fungi and both Gram-negative and Gram-pozitive bacteria (Table 1). Compound 3 have shown the best antifungal and antibacterial activity at (MIC) of 0.125 μg/mL and 2.5 μg/mL, respectively. Compounds 1, 2 and 4 possess activity comparable with reference compounds Caspofungin and Kanamycin (4 μg/mL). Table. Results of in vitro testing of antibacterial and antifungal activity of compounds 1-4.tabel