Japanese honeysuckle (Lonicera japonica Thumb.) is a species belonging to Caprifoliaceae family. These are creeping plants native to Asian countries (China, Japan and Korea), known more for their decorative properties. More than 212 chemical compounds have been isolated from the plants of this species, which primarily include organic acids, flavonoids, iridoids, triterpenoids and other volatile terpenic components [1-3]. Pharmacological studies have shown that L. japonica possess antibacterial, antiviral, anti-inflammatory, antipyretic, liver and gall bladder-protective, anti-oxidative, anti-fertility, hypolipidemic, anti-allergic and immuno-regulatory effects [4]. The GC-MS analysis of L. japonica oil of Moldavian origin resulted in identification of twenty-seven components (Table), which represent 99.47% of the total oil constituents. Table. Phytochemical composition of L. japonica essential oiltabelThe in vitro assessment of ethanolic extract from L. japonica plants have shown medium antibacterial activity against both non-pathogenic Gram-positive/Gram-negative (Bacillus subtilis and Pseudomonas fluorescens) and phytopathogenic (Xanthomonas campestris, Erwinia amylovora, E. carotovora) bacteria in the range of concentrations of 0.03-0.06%. Its antifungal properties against Candida utilis are higher at lower concentrations of 0.03%.