Functionalization of CHITOSANE with carboxyl acids and their use in the inhibition process of N-nitrosamins in cancer formation
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2021-02-02 09:45
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CEACÎRU, Mihail; GONTA, Maria; GUŢU, Iacob; CEACÎRU, Cristina. Functionalization of CHITOSANE with carboxyl acids and their use in the inhibition process of N-nitrosamins in cancer formation. In: Achievements and perspectives of modern chemistry. 9-11 octombrie 2019, Chişinău. Chisinau, Republic of Moldova: Tipografia Academiei de Ştiinţe a Moldovei, 2019, p. 212. ISBN 978-9975-62-428-2.
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Achievements and perspectives of modern chemistry 2019
Conferința "International Conference "Achievements and perspectives of modern chemistry""
Chişinău, Moldova, 9-11 octombrie 2019

Functionalization of CHITOSANE with carboxyl acids and their use in the inhibition process of N-nitrosamins in cancer formation


Pag. 212-212

Ceacîru Mihail, Gonta Maria, Guţu Iacob, Ceacîru Cristina
 
State University of Moldova
 
Disponibil în IBN: 11 noiembrie 2019


Rezumat

Cancer is a major health problem and is the second leading cause of death in the world. DNA oxidation can cause mutations and can therefore play an important role in the initiation and progression of carcinogenesis. For this reason, the imbalance between antioxidants and the levels of reactive oxygen species leads to oxidative alterations, which can occur at molecular levels. These processes can cause toxicity, mutations, and induction of cancereenose [1]. The role of oxidative stress in initiating and promoting cancer justifies the functional antioxidant approach in the prevention and treatment of cancer by developing inhibition methods in the carcinogenic Nnitrosoamines formation by the functionalization of chitosan with carboxylic acids, especially with dihydroxyfumaric acid. The functionalisation of chitosan was performed according to the scheme presented in the Figure. The anti-oxidant activity of the functionalized chitosan was determined by theDPPH test and it has been established that the antiradical power of the functionalized copolymer is 2.5 times higher than pure dihydroxyfumaric acid. These composites are to be used to inhibit the formation of N-nitrosamines in drug-nitrosation.formulaFigure. The reaction mechanism of chitosan grafting to dihydroxyfumaric acid. It has been developed a functionalization of chitosan with dihydroxyfumaric acid. The antiradical power of the functionalized copolymer was determined. Intermediate and final compounds have been demonstrated by IR, UV and H1-NMR spectra.