The issue of mitigating regional imbalances and, in general, supporting regional development processes is a major concern for analyzes designed to substantiate economic and social policy measures. Explaining the growing interest for such concerns lies in the need to address and resolve in the framework of the national economic policies of new difficulties generated in the context of the restructuring processes and the problems that arise in connection with the processes involved in the economic and political integration. The imbalance in the economic and social development of the Republic of Moldova has contributed to the emergence of major problems in the development of localities, including the concentration of development and growth trends in Chisinau, the decline of the cities, the underdevelopment of rural communities and the imbalance in the development between localities. Solving these problems is the main challenge for regional development policy.